{ "nid": "92", "details": "\x3cspan class=\"title\"\x3eNerveWorks™: Hyperkalemic Muscle\x3c/span\x3e\x3cbr/\x3e\n\x3cspan class=\"description\"\x3eIn this lab you use the intracellular recording technique to compare physiology of normal healthy muscle with diseased muscle from a patient with hyperkalemic periodic paralysis (HPP). HPP is a fairly rare inherited muscle disease caused by mutations in the gene that codes for the skeletal muscle voltage-gated Na\x3csup\x3e+\x3c/sup\x3e channel (specifically in the pore forming subunit of this channel). You record resting potential, threshold for action potential generation, effects of increasing levels of extracellular K, and effects of TTX on both healthy and diseased muscle. Your goal is to propose how mutation of the voltage-gated Na\x3csup\x3e+\x3c/sup\x3e channels leads to two different muscle problems: stiffness (sustained force generation) and weakness (inability to generate force). \x3cb\x3eThis is an advanced lab\x3c/b\x3e.\r\n\x3c/span\x3e\x3cbr/\x3e\n\x3cbr/\x3e\n\x3cstrong\x3eKey Concepts\x3c/strong\x3e: Hyperkalemia; Stimulation\x3cbr/\x3e\n\x3cstrong\x3eCourses\x3c/strong\x3e: Neurobiology\x3cbr/\x3e\n          \x3cbr/\x3e\x3ca href=\"/search_result_details/brief/92\" class=\"node_brief\"\x3eRead less\x3c/a\x3e        \x3cbr/\x3e  \x3c/span\x3e \x3c!-- description --\x3e\n" }