{ "nid": "68", "details": "\x3cspan class=\"title\"\x3eEvoBeaker™: Sickle-Cell Alleles\x3c/span\x3e\x3cbr/\x3e\n  \x3cdiv class=\"demo\"\x3e\x3ca href=\"http://www.simbio.com/demos/SickleCellDemo.mov\" target=\"_blank\"\x3e\x3cimg src=\"/files/demo_thumbnails/DemoThumb_SCA.jpg\" border=0 /\x3e\x3c/a\x3e\x3c/div\x3e\n\x3cspan class=\"description\"\x3eAn interactive simulation of the classic malaria and sickle-cell anemia system is used to explore natural selection and genetic drift. Students examine African villages with different malaria death rates. First they use the Hardy-Weinberg equation to calculate the expected proportion of sickle-cell carriers from HbS and HbA allele frequencies. Then they examine how the allele frequencies change with changes in malaria risk and with different \"founder\" scenarios. Finally they explore genetic drift without selection by looking at different-sized villages where both diseases have been cured. An optional advanced section allows independent exploration of evolutionary forces using a basic population genetics model with adjustable parameters for selection strength, immigration rate, and population size. This is one of our most popular labs for introductory biology courses.\r\n\r\n\x3c/span\x3e\x3cbr/\x3e\n\x3cbr/\x3e\n\x3cstrong\x3eLevel\x3c/strong\x3e: Intro\x3cbr/\x3e\n\x3cstrong\x3eKey Concepts\x3c/strong\x3e: Genetic drift; Hardy-Weinberg Equation; Natural selection\x3cbr/\x3e\n\x3cstrong\x3eCourses\x3c/strong\x3e: Evolution; Hardy-Weinberg; Intro Bio: Eco/Evo/Genetics; Intro Bio: Non-majors; Population Genetics\x3cbr/\x3e\n  \x3cstrong\x3eReviews:\x3c/strong\x3e\x3cbr /\x3e\n  \x3c/span\x3e \x3c!-- /description --\x3e\n\n        \n    \x3cblockquote\x3e\x3cem\x3e\x26quot;We used the Sickle-Cell EcoBeaker™ lab with all 1100 freshman enrolled in our majors biology course in the fall of 2003. The results truly impressed me — I felt like the students had a much stronger grasp of Hardy-Weinberg theory as a result of this interactive exercise and exam scores went up as well. \r\n\x26quot;\x3c/em\x3e\x3cbr /\x3e\n              Dr. Linda Walters, Central Florida University, Majors Introductory Biology\x3c/blockquote\x3e\x3cbr/\x3e\n      \n    \x3cblockquote\x3e\x3cem\x3e\x26quot;I had great success using your EcoBeaker™ labs, Keystone Predator and Sickle-Cell Alleles, in my BIO102 General Biology II class (4 lab sections, 96 students) this spring semester. \r\n\x26quot;\x3c/em\x3e\x3cbr /\x3e\n              Dr. Daniel Vogt, Plattsburgh State University, General Biology\x3c/blockquote\x3e\x3cbr/\x3e\n        \x3cbr/\x3e\x3ca href=\"/search_result_details/brief/68\" class=\"node_brief\"\x3eRead less\x3c/a\x3e    \x3cbr/\x3e\x3ca href=\"/cart/add/68\"\x3e + Add to course collection\x3c/a\x3e" }