{ "nid": "231", "details": "\x3cspan class=\"title\"\x3eNerveWorks™: LTP (Long-Term Potentiation)\x3c/span\x3e\x3cbr/\x3e\n\x3cspan class=\"description\"\x3eThis lab explores the properties of Long-Term Potentiation, and its relation to learning and memory. The lab begins with an overview of LTP and its history. Students then experiment on CA3 pyramidal neuons synapsing on a CA1 neuron. By eliciting spike trains in the presynaptic neuron, they see how LTP can change a subthreshold stimulus into a superthreshold stimulus.  They also generate depotentiation, and use these experimental protocols to explore the LTP mechanism.\x3c/span\x3e\x3cbr/\x3e\n\x3cbr/\x3e\n\x3cstrong\x3eKey Concepts\x3c/strong\x3e: Depotentiation; Long-term potentiation; Memory; Synapses\x3cbr/\x3e\n\x3cstrong\x3eCourses\x3c/strong\x3e: Neurobiology\x3cbr/\x3e\n          \x3cbr/\x3e\x3ca href=\"/search_result_details/brief/231\" class=\"node_brief\"\x3eRead less\x3c/a\x3e        \x3cbr/\x3e  \x3c/span\x3e \x3c!-- description --\x3e\n" }