NerveWorks™
NerveWorks™ is the first teaching program that allows students to construct their own virtual neurobiology rigs to record from simulated neurons they can build themselves, all with an intuitive drag-n-drop interface. Developed by a team at the University of Washington and enhanced by SimBiotic Software, the well-crafted NerveWorks™ goes beyond other neurobiology simulations in facilitating student experimental design and encouraging exploration. Labs cover a wide range of areas within neurophysiology, and are used in both introductory neurobiology classes and to train graduate students.
NerveWorks™ Pricing*
| Full package subscription with CD: $34/student/year Includes book and CD. |
| Full package subscription, download from webstore: $27/student/year Does not include workbooks. |
| For classes over 25 students that will only be using a few of the NerveWorks™ labs, we can arrange special pricing. Please contact us. |
*NOTE: due to price structure differences between NerveWorks™ and our other products, you can not use the pricing estimator to generate a price quote for a custom collection of these labs.
NerveWorks™ Labs
NerveWorks™: Recording 101
This tutorial lab introduces students to NerveWorks equipment and to intracellular recording techniques. ... Read more |
NerveWorks™: Historical Hodgkin Huxley
This is the first of several labs that recreate the famous Hodgkin-Huxley-Katz experiments on squid axons. ... Read more |
NerveWorks™: Pay Attention
In this lab you study how the catecholamine norepinephrine modulates the firing properties of hippocampal CA1 neurons (Madison and Nicoll, 1986). ... Read more |
NerveWorks™: Membrane Challenge
In this lab you explore how two factors affect cell resting potential: selective permeability of the cell membrane to ions and the concentration gradient for the permeant ion, in the sim ... Read more |
NerveWorks™: Advanced Resting Potential II: Ohmic
In this lab you record from a cell with a resting potential controlled by permeability of the membrane to ions that pass through "ohmic" leak channels. ... Read more |
NerveWorks™: LTP (Long-Term Potentiation)
This lab explores the properties of Long-Term Potentiation, and its relation to learning and memory. The lab begins with an overview of LTP and its history. ... Read more |
NerveWorks™: Neural Logic
In this lab you build functioning synapses, the basic signaling units of the nervous system, and construct a sequence of simple multi-cell neural networks that perform some of the basic logical calcul ... Read more |
NerveWorks™: Basic Resting Potential
In this lab you explore the basic factors that determine a cell's resting potential. First you record from a cell where only one ion is permeant at rest. ... Read more |
NerveWorks™: Synaptic Challenge
In this lab you record post-synaptic potentials (PSPs) in a target neuron in response to stimulation of two different "simulated" pre-synaptic inputs. ... Read more |
NerveWorks™: Voltage Clamp Basics
This tutorial teaches you how to use the NerveWorks two electrode voltage clamp and to record currents from cells that contain only leak channels in their membranes. ... Read more |
NerveWorks™: Hodgkin Huxley Action Potential
In this lab you repeat some of the key experiments from the 1949 paper of Hodgkin, Huxley, and Katz, showing that that Na+influx creates the depolarizing phase of the action potential and K ... Read more |
NerveWorks™: Hodgkin Huxley Na Inactivation
In this lab you explore the inactivation properties of Na+channels using the voltage clamp technique. ... Read more |
NerveWorks™: Hodgkin Huxley Voltage Clamp
In this lab you use the voltage clamp technique, solution composition changes and drugs to isolate voltage-activated Na+and K+ currents that generate the "typical" Hodg ... Read more |
NerveWorks™: Hyperkalemic Muscle
In this lab you use the intracellular recording technique to compare physiology of normal healthy muscle with diseased muscle from a patient with hyperkalemic periodic paralysis (HPP). ... Read more |
NerveWorks™: Ca Dependent K AHP
In this lab you use intracellular recording techniques to explore how calcium-activated K+ currents (IK (Ca )) modulate cell firing properties defined by more classic voltage-act ... Read more |
NerveWorks™: Ca Dependent K ICa Voltage Clamp
This is the second lab examining IK (Ca ). ... Read more |
NerveWorks™: Advanced Resting Potential I: GHK
In this exercise, you explore the behavior of a resting neuronal membrane permeable to both K+ and Na+. ... Read more |
NerveWorks™: IV Relations
This is an advanced and somewhat difficult lab using the voltage clamp to record Na+ current through voltage-gated Na channels. You generate a Current vs. ... Read more |
NerveWorks™: Voltage Clamp Hyperkalemic Muscle
This is a second part to the Hyperkalemic Muscle lab where you compare physiology of normal healthy muscle with diseased muscle from a patient with hyperkalemic periodic paralysis (HPP). ... Read more |
NerveWorks™: Vent Worm Action Potential
This laboratory is based on a totally fictitious, but plausible scenario. You are on an expedition to study neurons from tubeworms that live near deep sea hydrothermal vents. ... Read more |
NerveWorks™: Vent Worm Resting
This exercise is based on a totally fictitious, but plausible scenario: You retrieve vent worms (Riftia pachyptila) from deep sea hydrothermal vents to study in the laboratory. ... Read more |
NerveWorks™: Passive Properties of Neurons
In this lab you study the passive properties of the neuronal membrane by delivering stimuli to a cell and then modifying its resistance and capacitance to see how these affect its response. ... Read more |
NerveWorks™: Program Tour
NerveWorks™ Program Tour is a basic introduction to our software for users who are familiar with intracellular recording techniques. ... Read more |
NerveWorks™: Building Laboratories
Building Labs is a tutorial for teachers and developers that shows you how to build NerveWorks labs from scratch. ... Read more |
